Achilles is a fast paced, trail blazing bio-technology company focussed on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer company. Originating from pioneering research at Cancer Research UK (CRUK), the Francis Crick Institute and University College London (UCL), we use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient. From this, we develop personalised T cell therapies and currently have two programmes in the clinic for the treatment of Lung Cancer and Metastatic Malignant Melanoma.

As no-one has done what we are doing before, there is no playbook to copy. This means we must innovate, adapt and collaborate across our organisation, working together to solve novel problems. This entrepreneurial spirit and approach runs through our company and those who thrive here are able to cope with anything that is thrown at them, enjoy making sense of ambiguity and thrive on making things happen even when there is not a detailed brief.

Role Summary:

Due to team expansion we are looking to recruit an Associate Medical Director for our Clinical Development team.

The Associate Medical Director is primarily accountable for the medical monitoring of clinical trials to establish the overall benefit, risk and value of our current clinical trials and any future Investigational Medical Products.

Key Responsibilities:

Study Level Tasks

• Medical monitoring activities e.g.:
• Review subject eligibility and protocol deviations;  respond to site queries
• Train site teams and CRAs in the relevant therapy area, clinical study protocol and investigational product.
• Conduct regular medical review of safety, coding, labs and efficacy data to ensure accuracy and consistency
• Ensure data quality ahead of database locks for interim analyses of safety and efficacy
• Contribute to writing clinical protocols and other study-related documents
• Ensure rapid SAE processing and documentation (assessment, relatedness, queries, narratives)

Clinical Development Tasks

• Contribute to the Clinical Development Strategy
• Contribute to the design and interpretation of clinical studies.
• Ensure the safety of patients participating in Achilles clinical trials.
• Represent Achilles in interactions with external stakeholders (e.g., regulatory authorities, pricing and reimbursement bodies, key opinion leaders, advisory boards, potential industry partners, patient advocacy groups), and internal stakeholders.
• Contribute to the delivery of the  translational science strategy
• Effectively communicate project status, risks and issues
• Contribute to writing  clinical components of regulatory documents (e.g., Investigators’ Brochure, DSUR, clinical components of regulatory submissions
• Contribute to writing abstracts, presentations, and manuscripts.

Requirements

• MD with expertise in oncology or haematological malignancies, and relevant experience of clinical trials in either an industry or academic setting
• Excellent scientific and analytical skills
• Excellent interpersonal skills, with demonstrated ability to interact effectively with peers and a variety of stakeholders

Benefits

At Achilles you will enjoy a flexible and dynamic working environment that fosters creativity, leadership, and teamwork. We work hard and deliver a lot

Our benefits package includes a competitive salary and performance related bonus, group pension plan matched up to 6%, life insurance, private medical insurance, and a tax approved all employee share incentive plan.